Jump to main content
Jump to site search

Issue 16, 2018
Previous Article Next Article

Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells

Author affiliations

Abstract

Inspired by diverse marine bioactive compounds, the principle of molecular hybridization was applied to produce a series of new compounds combining diverse heterocyclic systems (oxa/thiazoles and tetrahydropyrans) via a triazole ring, attempting to increase the activity of individual building blocks. These new compounds exhibit a highly interesting antiproliferative activity against different human tumour cells and good selectivity when compared to normal cells. The formation of reactive oxygen species and the interaction with P-gp were also evaluated for the lead compounds.

Graphical abstract: Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 May 2018, accepted on 10 Jul 2018 and first published on 24 Jul 2018


Article type: Paper
DOI: 10.1039/C8NJ02388C
Citation: New J. Chem., 2018,42, 13784-13789
  •   Request permissions

    Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells

    G. Valdomir, M. D. L. Á. Fernández, I. Lagunes, J. I. Padrón, V. S. Martín, J. M. Padrón and D. Davyt, New J. Chem., 2018, 42, 13784
    DOI: 10.1039/C8NJ02388C

Search articles by author

Spotlight

Advertisements