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A Highly sensitive fluorescent probe for bioimaging Zinc Ion in Living Cells and Zebrafish Models

Abstract

Zn2+ plays fundamental roles in cellular metabolism and apotosis, as well as neurotransmission. However, it is still challenging and meaningful how to fast detect Zn2+ in biology. In this report, we rationally synthesized a simple off-on fluorescent probe for fast detection of Zn2+ based on intramolecular charge transfer and chelation enhanced fluorescence. Addition of Zn2+ into the probe induced a significant fluorescence enhancement with a bathochromic shift of 55 nm. Moreover, the probe demonstrated excellent sensitivity (detection limit = 0.072 μM) and outstanding selecitvity toward Zn2+ and ultra-fast response rate of two seconds. The recognition mechanism of the probe toward Zn2+ was fully confirmed by HRMS and 1H NMR spectra, as well as TDDFT calculations. Furthermore, the probe could rapidly light-up bioimaging Zn2+ in living cells and zebrafish models with low cytotoxicity and good biocompatibility.

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Supplementary files

Publication details

The article was received on 05 May 2018, accepted on 13 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ02197J
Citation: New J. Chem., 2018, Accepted Manuscript
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    A Highly sensitive fluorescent probe for bioimaging Zinc Ion in Living Cells and Zebrafish Models

    Z. Lu, W. Fan, Y. Lu, C. Fan, H. Zhao, K. Guo, W. Chu and Y. Lu, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ02197J

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