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Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper (II)-catalyzed asymmetric Henry reaction

Abstract

The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. Results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. Enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.

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Publication details

The article was received on 20 Apr 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8NJ01930D
Citation: New J. Chem., 2018, Accepted Manuscript
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    Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper (II)-catalyzed asymmetric Henry reaction

    A. Sacchetti, A. Rossetti, F. MENEGHETTI, C. Castellano, M. Mori, G. Colombo Dugoni and S. Landoni, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01930D

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