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Chiral electrochemical recognition of tryptophan enantiomers at a multi-walled carbon nanotube-N-carboxymethyl chitosan composite modified glassy carbon electrode

Abstract

A simple chiral electrochemical sensor based on N-carboxymethyl chitosan (NCCS) covalently binding with the ethylenediamine-carboxylic multiwalled carbon nanotubes (MWCNTs-EA) was developed for enantioselective recognition of tryptophan (Trp) enantiomers, NCCS preferably combined with L-Trp than D-Trp. The recognition efficiency was prominently increased after the introduction of N-carboxymethyl into chitosan (CS), the carboxymethyl and imino group of NCCS paly an important role in enantioselective discrimination system. Meanwhile, the parameters of enantioselective recognition such as pH, tempetrature and response time were investigated. The electrochemical recognition of amino acid enantiomers with different functional groups was carried out. The chiral recognition mechanism was investigated by quantum computing, the results were confirmed by the quantum chemistry calculation.

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Publication details

The article was received on 15 Apr 2018, accepted on 16 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01814F
Citation: New J. Chem., 2018, Accepted Manuscript
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    Chiral electrochemical recognition of tryptophan enantiomers at a multi-walled carbon nanotube-N-carboxymethyl chitosan composite modified glassy carbon electrode

    Z. Li, Z. Mo, P. Yan, S. Meng, R. Wang, X. Niu, N. liu and R. Guo, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01814F

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