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Novel insights into the effect of folate-albumin binding on the transport of ascorbic acid as an anticancer agent: Chemometric analysis based on combined spectroscopic and electrochemical studies

Abstract

One way of the cancer treatment is based on the generation of reactive oxygen species (ROS). Ascorbic acid is an effective nutrient commonly regarded as an antioxidant but it can act as a pro-oxidant at pharmacological concentrations. It can generate ascorbate radical and hydrogen peroxide which induce cytotoxicity toward different types of cancer cells in vitro. Although variety of cancer cells can be killed by ROS, development of pro-oxidant drugs has been limited by their toxicity to healthy cells. Tumor targeting with folic acid for selective targeting of folate receptor has been proposed as a promising strategy for cancer therapy and delivery of therapeutic agents such as ascorbic acid into tumor cells. Lately, it was offered the modification of folic acid conjugates with an albumin binding entity influence the function and bioavailability of drugs. The goal of this study was to evaluate the electrochemical behavior of the mixture of ascorbic acid and folic acid in the interaction with albumin on the basis of electrochemical techniques. Furthermore, the latter techniques and ultraviolet and visible (UV-Vis) spectrophotometry can reflect the redox activity of the complex species, electrochemical mechanisms and their biochemical behaviors in the generation of ROS. Also, this study revealed the molecular details of this binding, thermodynamic parameters and a novel and unexpected drug-binding site in the presence of other components using chemometric models and docking studies.

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Publication details

The article was received on 31 Mar 2018, accepted on 15 May 2018 and first published on 16 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01572D
Citation: New J. Chem., 2018, Accepted Manuscript
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    Novel insights into the effect of folate-albumin binding on the transport of ascorbic acid as an anticancer agent: Chemometric analysis based on combined spectroscopic and electrochemical studies

    S. Abbasi , S. Gharaghani, A. Benvidi and M. Rezaeinasab, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01572D

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