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Synthesis and Characterization of Novel Dimeric s-Triazine Derivatives as Potential Anti-Bacterial Agents against MDR Clinical Isolates

Abstract

A new library of dimeric s-triazine hydrazide derivatives was synthesized and fully characterized by IR, NMR, and elemental analysis. The synthesized compounds were screened for their in vitro antimicrobial activity. Some of these compounds were found to have more potent anti-bacterial activity compared with that of standard drug Ampicillin trihydrate. The compounds which displayed the lowest MIC values, such as compounds 1, 12, 13, 20d, 21d, 22d were further screened for their antibacterial activity against MDR (multi drug resistant) clinical isolates. In contrast to the reference drug Ampicillin, the tested compounds revealed significantly low MIC values towards the tested MDR strains. The most active compounds 1, 12, 13, 20d, 21d and 22d showed high selectivity index toward antimicrobial activity against K. pneumoniae and MRSA1 than mammalian cells, suggesting good safety profile.

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Publication details

The article was received on 26 Mar 2018, accepted on 17 May 2018 and first published on 18 May 2018


Article type: Paper
DOI: 10.1039/C8NJ01483C
Citation: New J. Chem., 2018, Accepted Manuscript
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    Synthesis and Characterization of Novel Dimeric s-Triazine Derivatives as Potential Anti-Bacterial Agents against MDR Clinical Isolates

    D. R. Ramadan, A. A. El Bardan, A. A. Bekhit, A. El-Faham and S. Khattab, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ01483C

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