Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

Dicarboxylato platinum(II) complexes containing dimethyl sulfoxide and triazolopyrimidine as potential anticancer agents: synthesis, structural and biological studies in solution

Author affiliations

Abstract

Four dicarboxylato platinum(II) complexes of the general formula [Pt(R(COO)2)(dmso)(N-donor)], where: R(COO)2 – cyclobutane-1,1-dicarboxylato or malonato, dmso – dimethyl sulfoxide and N-donor – 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) or 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), have been synthesized and structurally characterized using multinuclear magnetic resonance (1H, 13C, 15N, and 195Pt) techniques. The NMR parameters unambiguously confirmed the square-planar geometry of Pt(II) in solution with monodentate N(3)-bonded 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidine, monodentate and S-bonded dimethyl sulfoxide and O,O-chelating dicarboxylate ions. The obtained platinum(II) complexes exhibit (i) higher susceptibility to hydrolysis and (ii) lower toxicity and affinity to glutathione in comparison with cisplatin and carboplatin. Additionally, it is noted that two lipophilic platinum(II) complexes: (3) [Pt(mal)(dmso)(dptp)] and (4) [Pt(CBDC)(dmso)(dptp)] display the most gratifying in vitro antiproliferative activity. Above and beyond, these promising coordination compounds exhibit definitely lower toxicity towards normal cells and anticancer activity comparable to that of cisplatin.

Graphical abstract: Dicarboxylato platinum(ii) complexes containing dimethyl sulfoxide and triazolopyrimidine as potential anticancer agents: synthesis, structural and biological studies in solution

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Mar 2018, accepted on 27 Apr 2018 and first published on 27 Apr 2018


Article type: Paper
DOI: 10.1039/C8NJ01199K
Citation: New J. Chem., 2018,42, 8113-8122
  •   Request permissions

    Dicarboxylato platinum(II) complexes containing dimethyl sulfoxide and triazolopyrimidine as potential anticancer agents: synthesis, structural and biological studies in solution

    M. Jakubowski, I. Łakomska, J. Sitkowski and J. Wiśniewska, New J. Chem., 2018, 42, 8113
    DOI: 10.1039/C8NJ01199K

Search articles by author

Spotlight

Advertisements