Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Natural solvent-assisted synthesis of amphiphilic co-polymeric nanomicelles for prolonged release of camptothecin delivery

Author affiliations

Abstract

Biomaterials developed using sustainable methods and non-toxic solvents have been effectively applied as eco-friendly, sustainable reaction medium and catalysts for biological applications. This study describes the development of ε-caprolactone-citric acid nanomicelles using deep eutectic solvents (DESs) in the form of choline chloride and citric acid. The solvent formation was confirmed by FT-IR and 1H NMR spectroscopy. The highest polycondensation yield of ε-caprolactone (ε-cp) with citric acid (CA) poly(ε-cp-co-CA) was obtained in 1 : 2 DES medium. Camptothecin (CPT), used as a model anticancer agent, was encapsulated by poly(ε-cp-co-CA) micelles, which act as drug carriers. Micelle formation was determined by fluorescence analysis using pyrene (CMC = 0.5 mg mL−1). The self-assembled CPT-loaded poly(ε-cp-co-CA) micelles were characterized using FT-IR, XRD, SEM and TEM techniques. The size of the nanomicelles was observed to be ∼270 nm using dynamic light scattering (DLS) techniques. The encapsulation efficiency and in vitro profiles of CPT in poly(ε-cp-co-CA) micelles were investigated by UV spectrometry at λmax of 350 nm. The antiproliferative effect of the encapsulated CPT, which was investigated in A549 cells, suggested that ε-cp-co-CA may be a promising anticancer drug carrier.

Graphical abstract: Natural solvent-assisted synthesis of amphiphilic co-polymeric nanomicelles for prolonged release of camptothecin delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Feb 2018, accepted on 09 May 2018 and first published on 10 May 2018


Article type: Paper
DOI: 10.1039/C8NJ00901E
Citation: New J. Chem., 2018,42, 10366-10375
  •   Request permissions

    Natural solvent-assisted synthesis of amphiphilic co-polymeric nanomicelles for prolonged release of camptothecin delivery

    P. Pradeepkumar, A. M. Elgorban, A. H. Bahkali and M. Rajan, New J. Chem., 2018, 42, 10366
    DOI: 10.1039/C8NJ00901E

Search articles by author

Spotlight

Advertisements