Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

Iron(III) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

Author affiliations

Abstract

Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (e.g., hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(III) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(III) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution.

Graphical abstract: Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Dec 2017, accepted on 16 Mar 2018 and first published on 19 Mar 2018


Article type: Paper
DOI: 10.1039/C7NJ04867J
Citation: New J. Chem., 2018,42, 8074-8087
  •   Request permissions

    Iron(III) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity

    X. Martin-Benlloch, A. Novodomska, D. Jacquemin, E. Davioud-Charvet and M. Elhabiri, New J. Chem., 2018, 42, 8074
    DOI: 10.1039/C7NJ04867J

Search articles by author

Spotlight

Advertisements