Jump to main content
Jump to site search


A Zwitterionic Near-infrared Dye Linked TrkC Targeting Agent for Imaging Metastatic Breast Cancer

Abstract

Much effort has been devoted to targeting agents for imaging and chemotherapy of tumors in cancer research, but there remains significant unmet needs in that area. We have reported a series of preclinical TrkC targeting agents for diagnoses and treatment of metastatic breast cancer; however, with respect to optical imaging, there are limitations to the agents already disclosed. In this work, a TrkC targeting fragment was equipped with a zwitterionic cyanine dye to give a near-infrared probe for in vivo imaging of metastatic breast tumors, with excitation and emission wavelengths of 760 and 780 nm, respectively, and facilitated the aqueous dissolution of the final design. To our delight, the newly developed probe maintained the specific targeting to TrkC+ 4T1 metastatic breast tumor cells as well as TrkC+ metastatic breast tumor tissue. Upon injection into 4T1-tumor-bearing mice, the tumor was visualized in vivo and ex vivo through the fluorescent signal of the probe. These data seem encouraging for further investigations toward developing a TrkC targeting agent for diagnosis of metastatic breast tumors.

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Apr 2018, accepted on 25 Jul 2018 and first published on 03 Aug 2018


Article type: Research Article
DOI: 10.1039/C8MD00190A
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
  •   Request permissions

    A Zwitterionic Near-infrared Dye Linked TrkC Targeting Agent for Imaging Metastatic Breast Cancer

    Z. Yang, S. M. Usama , F. Li, K. Burgess and Z. Li, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00190A

Search articles by author

Spotlight

Advertisements