Jump to main content
Jump to site search


Scaffold hopping from synthetic RXR modulators by virtual screening and de novo design

Author affiliations

Abstract

The lack of potent subtype-selective modulators of retinoid X receptors (RXRs) has hindered their full exploitation as promising drug targets. Using computational similarity searching, target prediction and automated de novo design, we identified novel RXR ligands exhibiting innovative molecular frameworks, pronounced receptor-subtype preference and suitable properties for hit-to-lead expansion.

Graphical abstract: Scaffold hopping from synthetic RXR modulators by virtual screening and de novo design

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Mar 2018, accepted on 15 Apr 2018 and first published on 06 Jun 2018


Article type: Research Article
DOI: 10.1039/C8MD00134K
Citation: Med. Chem. Commun., 2018, Advance Article
  •   Request permissions

    Scaffold hopping from synthetic RXR modulators by virtual screening and de novo design

    D. Merk, F. Grisoni, L. Friedrich, E. Gelzinyte and G. Schneider, Med. Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8MD00134K

Search articles by author

Spotlight

Advertisements