Jump to main content
Jump to site search


Synthesis and Antiplasmodial Activity of Purine Based C-Nucleoside Analogues

Abstract

A series of homologous C-nucleoside mimics have been synthesized via an efficient and facile synthetic protocol involving the conjugate addition of purine to sugar derived olefinic ester in good yields. The synthesized compounds were evaluated for their antiplasmodial activity in vitro against both the CQ sensitive and resistant strains of P. falciparum. Interestingly all the synthesized nucleoside analogs exhibited IC50 of < 5 µM, while compounds 22a, 23a, and 23b showed promising antiplasmodial activity with IC50 of 1.61, 0.88, 1.01 μM against CQ sensitive Pf3D7 strain and 1.14, 1.01, 2.57 μM against CQ resistant PfK1 strain, respectively.

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Feb 2018, accepted on 25 May 2018 and first published on 29 May 2018


Article type: Research Article
DOI: 10.1039/C8MD00098K
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
  •   Request permissions

    Synthesis and Antiplasmodial Activity of Purine Based C-Nucleoside Analogues

    K. Singh, P. Joshi, R. Mahar, P. Baranwal, S. K. Shukla, R. Tripathi and R. P. Tripathi, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00098K

Search articles by author

Spotlight

Advertisements