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Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

Abstract

In the present study, we investigated the anti-tumor activities of the intracellular homogeneous melanin (LM) of Lachnum YM226 and its derivative (ALM) on liver cancer using murine H22 hepatocarcinoma model. The results showed that LM and ALM (50 and 200 mg/kg) could effectively inhibit the tumor growth of H22 tumour-bearing mice. The body weight, liver, spleen and thymus indexes were also improved in LM and ALM treated groups. Moreover, the levels of alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid (UA) were lowered. Serum cytokines of interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were increased by LM and ALM administration, while LM and ALM significantly decreased the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) levels. The H&E staining indicated that LM and ALM exhibited antitumor activity in vivo by promoting apoptosis and inhibiting angiogenesis. The anti-tumor effect of ALM was more obvious than that of LM at the same dose. Summarily, the findings demonstrated that LM and ALM might be a promising candidate for the prevention and treatment of HCC.

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Publication details

The article was received on 20 Jan 2018, accepted on 08 May 2018 and first published on 16 May 2018


Article type: Research Article
DOI: 10.1039/C8MD00035B
Citation: Med. Chem. Commun., 2018, Accepted Manuscript
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    Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

    F. Shi, J. Li, Z. Ye, L. Yang, T. Chen, X. Chen and M. Ye, Med. Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8MD00035B

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