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Issue 4, 2018
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Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD

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Abstract

In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents. Some of the compounds considerably protected HUVECs against 60Co γ-irradiation, accompanied by the absence of cytotoxicity. Compared to Ex-RAD, compound 8n not only exhibited a significant protective effect on cell survival and radiation-induced DNA damage, but also remarkably enhanced the survival (100%) of mice in 30 days after being exposed to irradiation. The results suggested that some target compounds are valuable for further research as promising radioprotectors.

Graphical abstract: Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD

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Publication details

The article was received on 13 Nov 2017, accepted on 09 Feb 2018 and first published on 19 Feb 2018


Article type: Research Article
DOI: 10.1039/C7MD00573C
Citation: Med. Chem. Commun., 2018,9, 625-631
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    Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD

    L. Tang, T. Peng, G. Wang, X. Wen, Y. Sun, S. Zhang, S. Liu and L. Wang, Med. Chem. Commun., 2018, 9, 625
    DOI: 10.1039/C7MD00573C

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