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In-droplet microparticle washing and enrichment using surface acoustic wave-driven acoustic radiation force

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Abstract

Washing and enrichment of particles and cells are crucial sample preparation procedures in biomedical and biochemical assays. On-chip in-droplet microparticle washing and enrichment have been pursued but remained problematic due to technical difficulties, especially simultaneous and precise control over the droplet interface and in-droplet samples. Here, we have achieved a breakthrough in label-free, continuous, on-demand, in-droplet microparticle washing and enrichment using surface acoustic waves. When exposed to the acoustic field, the droplet and suspended particles experience acoustic radiation force arising from inhomogeneous wave scattering at the liquid/liquid and liquid/solid interfaces. Based on these acoustophoretic phenomena, we have demonstrated in-droplet microparticle washing and enrichment in an acoustofluidic device. We expect that the proposed acoustic method will offer new perspectives to sample washing and enrichment by performing the operation in microscale droplets.

Graphical abstract: In-droplet microparticle washing and enrichment using surface acoustic wave-driven acoustic radiation force

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Publication details

The article was received on 13 Jul 2018, accepted on 20 Aug 2018 and first published on 20 Aug 2018


Article type: Paper
DOI: 10.1039/C8LC00733K
Citation: Lab Chip, 2018, Advance Article
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    In-droplet microparticle washing and enrichment using surface acoustic wave-driven acoustic radiation force

    J. Park, G. Destgeer, H. Kim, Y. Cho and H. J. Sung, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00733K

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