Jump to main content
Jump to site search


High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets

Author affiliations

Abstract

A generic approach is presented that allows high-resolution NMR spectroscopy of water/oil droplet emulsions in microfluidic devices. Microfluidic NMR spectroscopy has recently made significant advances due to the design of micro-detector systems and their successful integration with microfluidic devices. Obtaining NMR spectra of droplet suspensions, however, is complicated by the inevitable differences in magnetic susceptibility between the chip material, the continuous phase, and the droplet phases. This leads to broadening of the NMR resonance lines and results in loss of spectral resolution. We have mitigated the susceptibility difference between the continuous (oil) phase and the chip material by incorporating appropriately designed air-filled structures into the chip. The susceptibilities of the continuous and droplet (aqueous) phases have been matched by doping the droplet phase with a Eu3+ complex. Our results demonstrate that this leads to a proton line width in the droplet phase of about 3 Hz, enabling high-resolution NMR techniques.

Graphical abstract: High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets

Back to tab navigation

Publication details

The article was received on 09 Jul 2018, accepted on 15 Aug 2018 and first published on 22 Aug 2018


Article type: Paper
DOI: 10.1039/C8LC00712H
Citation: Lab Chip, 2018, Advance Article
  •   Request permissions

    High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets

    W. Hale, G. Rossetto, R. Greenhalgh, G. Finch and M. Utz, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00712H

Search articles by author

Spotlight

Advertisements