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Distributed fibre optofluidic laser for chip-scale arrayed biochemical sensing

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Abstract

Optofluidic lasers (OFLs) are an emerging technological platform for biochemical sensing, and their good performance especially high sensitivity has been demonstrated. However, high-throughput detection with an OFL remains a major challenge due to the lack of reproducible optical microcavities. Here, we introduce the concept of a distributed fibre optofluidic laser (DFOFL) and demonstrate its potential for high-throughput sensing applications. Due to the precise fibre geometry control via fibre drawing, a series of identical optical microcavities uniformly distributed along a hollow optical fibre (HOF) can be achieved to obtain a one-dimensional (1D) DFOFL. An enzymatic reaction catalysed by horseradish peroxidase (HRP) can be monitored over time, and the HRP concentration is detected by DFOFL-based arrayed colorimetric detection. Experimentally, five-channel detection in parallel with imaging has been demonstrated. Theoretically, spatial multiplexing of hundreds of channels is achievable with DFOFL-based detection. The DFOFL wavelength is tuned over hundreds of nanometers by optimizing the dye concentration or reconfiguring the liquid gain materials. Extending this concept to a two-dimensional (2D) chip through wavelength multiplexing can further enhance its multi-functionality, including multi-sample detection and spectral analysis. This work opens the door to high-throughput biochemical sensing.

Graphical abstract: Distributed fibre optofluidic laser for chip-scale arrayed biochemical sensing

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Publication details

The article was received on 22 Jun 2018, accepted on 03 Aug 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8LC00638E
Citation: Lab Chip, 2018, Advance Article
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    Distributed fibre optofluidic laser for chip-scale arrayed biochemical sensing

    C. Gong, Y. Gong, X. Zhao, Y. Luo, Q. Chen, X. Tan, Y. Wu, X. Fan, G. Peng and Y. Rao, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00638E

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