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Microfabricated devices for oral drug delivery

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Abstract

Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication. The physical barriers in the body, low pH of the stomach and degradation by enzymes in the gastrointestinal tract are a few of the obstacles to succeeding with oral drug delivery. Microfabricated devices show promise to overcome some of these hindrances and thereby improve the bioavailability of drugs after oral administration. There is an increasing focus on microfabricated oral drug delivery systems, and so far there have been three main groups of designs: patch-like structures, microcontainers and microwells. Here, we review the newest development in top-down microfabricated devices for oral drug delivery with coverage of the aspects of design, choice of material and fabrication techniques. Furthermore, the drug loading techniques and methods for testing are discussed. In addition, we discuss the future perspectives for microfabricated devices.

Graphical abstract: Microfabricated devices for oral drug delivery

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Publication details

The article was received on 18 Apr 2018, accepted on 26 Jun 2018 and first published on 02 Jul 2018


Article type: Critical Review
DOI: 10.1039/C8LC00408K
Citation: Lab Chip, 2018, Advance Article
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    Microfabricated devices for oral drug delivery

    L. H. Nielsen, S. S. Keller and A. Boisen, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00408K

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