Jump to main content
Jump to site search


Highly integrated autonomous lab-on-a-chip device for on-line and in situ determination of environmental chemical parameters

Author affiliations

Abstract

The successful integration of sample pretreatment stages, sensors, actuators and electronics in microfluidic devices enables the attainment of complete micro total analysis systems, also known as lab-on-a-chip devices. In this work, we present a novel monolithic autonomous microanalyzer that integrates microfluidics, electronics, a highly sensitive photometric detection system and a sample pretreatment stage consisting on an embedded microcolumn, all in the same device, for on-line determination of relevant environmental parameters. The microcolumn can be filled/emptied with any resin or powder substrate whenever required, paving the way for its application to several analytical processes: separation, pre-concentration or ionic-exchange. To promote its autonomous operation, avoiding issues caused by bubbles in photometric detection systems, an efficient monolithic bubble removal structure was also integrated. To demonstrate its feasibility, the microanalyzer was successfully used to determine nitrate and nitrite in continuous flow conditions, providing real time and continuous information.

Graphical abstract: Highly integrated autonomous lab-on-a-chip device for on-line and in situ determination of environmental chemical parameters

Back to tab navigation

Publication details

The article was received on 26 Mar 2018, accepted on 30 May 2018 and first published on 30 May 2018


Article type: Paper
DOI: 10.1039/C8LC00309B
Citation: Lab Chip, 2018, Advance Article
  •   Request permissions

    Highly integrated autonomous lab-on-a-chip device for on-line and in situ determination of environmental chemical parameters

    C. Martinez-Cisneros, Z. da Rocha, A. Seabra, F. Valdés and J. Alonso-Chamarro, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00309B

Search articles by author

Spotlight

Advertisements