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Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

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Abstract

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

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Publication details

The article was received on 17 Mar 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8LC00273H
Citation: Lab Chip, 2018, Advance Article
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    Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

    N. Hao, Y. Nie, T. Shen and J. X. J. Zhang, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00273H

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