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Investigation of iron oxidative state in ovarian cancer using synchrotron micro X-ray absorption near edge structure – preliminary results.

Abstract

Iron as a trace element plays a role in regulating the homeostasis of the human body and therefore the concentration of iron in the body must be carefully monitored. Both a deficiency and overload of iron could have a serious effect on health. Iron in excess can be carcinogenic in different ways. As a catalyst of Fenton’s reaction it leads to the creation of reactive oxygen species which causes oxidative stress and DNA damage, among other things. Iron also can reduce the response of the immune system to cancer and induce increased cancer cell proliferation. Ovarian cancer is one of the most common neoplasms in women and has a low survival rate. For this reason, there is strong motivation to deepen understanding of the processes that lead to the disease and take place in ovarian cancer tissue. In this study, the cryo micro X-Ray Absorption Near Edge Structure spectroscopy was used to analyse the oxidation state of iron in ovarian cancer samples. For calibration organic and inorganic reference samples containing Fe in different oxidation states were used. To determine the trace element in the neoplasm samples the pre-edge region, white line and absorption edge position of Fe K-edge XANES were examined and compared to the recorded reference materials. A comparison of these XANES spectra features shows the existence of differences in the iron oxidation state between the neoplasm samples and suggested the possibility that a combination of iron ions can occur in one sample. Overall, further investigations are required to compare better and determine what organic compounds are contained in the samples and possibly to carry out a statistical analysis.

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Publication details

The article was received on 03 May 2018, accepted on 13 Jul 2018 and first published on 13 Jul 2018


Article type: Paper
DOI: 10.1039/C8JA00140E
Citation: J. Anal. At. Spectrom., 2018, Accepted Manuscript
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    Investigation of iron oxidative state in ovarian cancer using synchrotron micro X-ray absorption near edge structure – preliminary results.

    D. Krauze, M. Grzelak, P. M. Wrobel, G. Veronesi, H. Castillo-Michel, L. Chmura, R. Jach, D. Adamek and M. Lankosz, J. Anal. At. Spectrom., 2018, Accepted Manuscript , DOI: 10.1039/C8JA00140E

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