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Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction

Abstract

Using whole cells of Escherichia coli co-expressing alcohol dehydrogenase (PsADH) and formate dehydrogenase (CpFDH) in a biphasic aqueous-soybean oil system is shown to be an efficient method for the biosynthesis of enantiopure tolvaptan. In this system, (S)-tolvaptan with an optical purity of 99.5% and bioconversion efficiency of 86.1% was achieved.

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Publication details

The article was received on 07 Dec 2017, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C7GC03679E
Citation: Green Chem., 2018, Accepted Manuscript
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    Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction

    H. Zhang, C. Zhang, M. Han, C. Pei, Z. Xu and W. Li, Green Chem., 2018, Accepted Manuscript , DOI: 10.1039/C7GC03679E

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