Issue 1, 2018
From the journal:

Green Chemistry

Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents†

Andree Iemhoff,ab   James Sherwood, ORCID logo a   Con R. McElroya  and  Andrew J. Hunt ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK

b Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany

c Materials Chemistry Research Center, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
E-mail: andrew@kku.ac.th

Abstract

The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.

Graphical abstract: Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C7GC03177G
Article type
Communication
Submitted
21 Oct 2017
Accepted
30 Nov 2017
First published
01 Dec 2017

Green Chem., 2018,20, 136-140

Permissions

Request permissions

Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

A. Iemhoff, J. Sherwood, C. R. McElroy and A. J. Hunt, Green Chem., 2018, 20, 136 DOI: 10.1039/C7GC03177G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements