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Issue 9, 2018
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Anti-inflammatory bowel effect of industrial orange by-products in DSS-treated mice

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Abstract

This work addresses the role of different by-products derived from the industrial extraction of orange juice in a possible anti-inflammatory effect in mice with colitis induced by dextran sulfate sodium (DSS). Fresh orange residue (FOR), dry orange residue (DOR), orange liqueur (OL) and animal feed (AF), as well as commercial citrus pectin (CP), were administered to C57BL/6J mice for 15 days before starting the DSS treatment. Analysis of macroscopic parameters such as the Disease Activity Index (DAI) and the colonic weight/length ratio revealed an anti-inflammatory effect following intake of FOR, AF or CP. Moreover, q-PCR of RNA from colonic tissue indicated measurable changes in the expression of TNF-α, IL-1β, iNOS, and intercellular adhesion molecules ICAM I, as well as in intestinal barrier proteins such as MUC-3, occludin, and ZO-1. Pectin, phenolic compounds and/or Maillard reaction products formed at initial steps were identified as relevant components exerting the ascribed beneficial effects. Our findings could open up the further application of a variety of orange by-products as food supplements in the potential amelioration of inflammatory bowel diseases.

Graphical abstract: Anti-inflammatory bowel effect of industrial orange by-products in DSS-treated mice

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Publication details

The article was received on 28 May 2018, accepted on 07 Aug 2018 and first published on 23 Aug 2018


Article type: Paper
DOI: 10.1039/C8FO01060A
Citation: Food Funct., 2018,9, 4888-4896
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    Anti-inflammatory bowel effect of industrial orange by-products in DSS-treated mice

    M. T. Pacheco, T. Vezza, P. Diez-Echave, P. Utrilla, M. Villamiel and F. J. Moreno, Food Funct., 2018, 9, 4888
    DOI: 10.1039/C8FO01060A

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