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Laurus nobilis (laurel) aqueous leaves extract toxicological and anti-tumor activities in HPV16-transgenic mice

Abstract

Cancers induced by human papillomavirus (HPV) infection remain a significant public health threat, fueling the study of new therapies. Laurel (Laurus nobilis) compounds and extracts recently showed in vitro activity against HPV-transformed cell lines. This work aims to evaluate the in vivo efficacy and hepatic toxicity of a laurel extract, in a transgenic mouse model of HPV16-induced cancer. The extract was administered in drinking water (20 mg/animal/day) for three consecutive weeks, using four experimental groups (n=10) (group I: HPV16-/- without treatment, group II: treated HPV16-/-, group III: HPV16+/- without treatment and group IV: treated HPV16+/-). Following the treatment period animals were sacrificed and skin samples were used to classify skin lesions histologically. Toxicological parameters included hematological and biochemical blood markers, splenic and hepatic histology and hepatic oxidative stress. The extract did not prevent the progression of HPV16-induced cutaneous lesions in this model. Treated wild-type animals showed mild hepatitis, while transgenic animals suffered weight loss. However, there were no changes concerning hematological, biochemical and hepatic oxidative stress markers.

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Publication details

The article was received on 24 Apr 2018, accepted on 10 Jul 2018 and first published on 11 Jul 2018


Article type: Paper
DOI: 10.1039/C8FO00783G
Citation: Food Funct., 2018, Accepted Manuscript
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    Laurus nobilis (laurel) aqueous leaves extract toxicological and anti-tumor activities in HPV16-transgenic mice

    B. Fonseca, V. Mestre, B. Colaço, M. Pires, T. Martins, R. Gil da Costa, M. Neuparth, R. Medeiros, M. Moutinho, M. I. Dias, L. Barros, M. Bastos, L. M. Félix, C. Venâncio, I. C. F. R. Ferreira, L. Antunes and P. A. Oliveira, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00783G

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