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Comparative analysis of fecal phenolic content between normal and obese rats after oral administration of tea polyphenols

Abstract

Tea polyphenols (TP) have many health benefits, but most are metabolized into low molecular-weight phenolic acids after oral administration. In the present study, the absorption, metabolism, and excretion of catechins in rats fed a normal chow diet and in obese rats fed a high-fat and high-sugar (HFHS) diet were compared. After a ten-day oral administration of TP (500 mg/kg.bw), the plasma levels of (-)-epigallocatechin gallate (EGCG) and (-)-gallocatechin gallate (GCG) in obese rats were significantly lower than in the normal group. In obese rats the fecal levels of EGCG, (-)-epicatechin gallate (ECG) and GCG were significantly enhanced. Ten phenolic metabolites of TP were quantitatively analyzed, and the results showed that 4-hydroxyphenylacetic acid was the primary metabolite in feces and plasma. The plasma and fecal concentrations of 4-hydroxyphenylacetic acid in the obese group were significantly lower than in normal rats, but the levels of 4-hydroxyphenylpropionic acid in plasma and feces were increased. The content of other phenolic acids were also dramatically changed. These results suggested that a HFHS diet might influence the excrection of tea catechins, leading to insufficient metabolism of catechins by gut microflora.

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Publication details

The article was received on 30 Mar 2018, accepted on 02 Aug 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8FO00609A
Citation: Food Funct., 2018, Accepted Manuscript
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    Comparative analysis of fecal phenolic content between normal and obese rats after oral administration of tea polyphenols

    B. Chen, J. Zhou, Q. Meng, Y. Zhang, S. Zhang and L. Zhang, Food Funct., 2018, Accepted Manuscript , DOI: 10.1039/C8FO00609A

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