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Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes

Abstract

Biomimetic ion channels can be made to display the high sensitivity of natural protein nanopores and to develop new properties as a function of the material used. How to design the best future biomimetic channel? The main challenges are to control their sensitivity, as well as their synthesis, chemical modifications, insertion and lifetime into a lipid membrane. To address these challenges, we have recently designed short cyclodextrin nanotubes characterized by mass spectrometry and high-resolution transmission electron microscopy. They form non-permanent ion channels into lipid bilayer. Here we show how to improve the nanotube insertion in order to limit multiple insertions, how to stabilize biomimetic channels into the membrane, how to understand the ion dynamics in confined medium scale.

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Publication details

The article was received on 15 Feb 2018, accepted on 26 Mar 2018 and first published on 26 Mar 2018


Article type: Paper
DOI: 10.1039/C8FD00030A
Citation: Faraday Discuss., 2018, Accepted Manuscript
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    Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes

    L. Bacri, Hajar. Mamad-Hemouch, C. Przybylski, B. Thiebot, G. Patriarche, N. Jarroux and J. Pelta, Faraday Discuss., 2018, Accepted Manuscript , DOI: 10.1039/C8FD00030A

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