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Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

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Abstract

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.

Graphical abstract: Acridine-decorated cyclometallated gold(iii) complexes: synthesis and anti-tumour investigations

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Publication details

The article was received on 19 Jun 2018, accepted on 30 Aug 2018 and first published on 03 Sep 2018


Article type: Paper
DOI: 10.1039/C8DT02507J
Citation: Dalton Trans., 2018, Advance Article
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    Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

    M. R. M. Williams, B. Bertrand, J. Fernandez-Cestau, Z. A. E. Waller, M. A. O'Connell, M. Searcey and M. Bochmann, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT02507J

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