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Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

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Abstract

The two series of ruthenium–indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental–theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

Graphical abstract: Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

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Publication details

The article was received on 12 Jun 2018, accepted on 05 Jul 2018 and first published on 05 Jul 2018


Article type: Communication
DOI: 10.1039/C8DT02408A
Citation: Dalton Trans., 2018, Advance Article
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    Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

    L. Chung, S. Ng, C. Yeung, H. Shek, S. Tse, H. Lo, S. Chan, M. Tse, S. Yiu and C. Wong, Dalton Trans., 2018, Advance Article , DOI: 10.1039/C8DT02408A

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