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Mesoporous SBA-15 Modified with Titanocene Complexes and Ionic liquids: Interactions with DNA and other Molecules of Biological Interest Studied by Solid State Electrochemical Techniques

Abstract

Immobilization of two titanocene complexes on SBA-15 has been accomplished following post synthetic procedures. The ionic liquid, 1-methyl-3-[(triethoxysilyl)propyl]imidazolium chloride, has also been incorporated into the titanium containing materials in order to determine its influence in the interaction with molecules of biological interest. Cyclic voltammetry has been used to study the influence of the ionic liquid on the mechanism of reduction of titanocene derivatives. The interaction of titanocene and titanocene / ionic liquid-containing mesoporous silica SBA-15 materials with molecules of biological interest associated with important processes of metallodrug action against cancer cells has been studied. Thus, we have carried out hydrolysis experiments of the materials functionalized with titanocene derivatives in physiologic medium to determine their stability and the interaction with serum / transport proteins such as transferrin and BSA and with target molecules such as guanosine, single stranded DNA and double-stranded DNA by means of solid state voltammetry techniques. A qualitative analysis of the data based on peak current and reduction potential value changes of the couple Ti(IV) / Ti(III) in the presence of biomolecules at physiological pH has revealed that grafted titanocene complexes show higher affinity for serum / transport proteins than for nucleic acids indicating that the transportation steps to cell may be easier than the subsequent attack to DNA

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Publication details

The article was received on 17 May 2018, accepted on 30 Jul 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8DT02011F
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Mesoporous SBA-15 Modified with Titanocene Complexes and Ionic liquids: Interactions with DNA and other Molecules of Biological Interest Studied by Solid State Electrochemical Techniques

    I. del Hierro, S. Gómez-Ruiz, Y. Pérez, P. Cruz, S. Prashar and M. Fajardo, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT02011F

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