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Peptide Metal-Organic Frameworks under pressure: flexible linkers for cooperative compression

Abstract

We investigate the structural response of a dense peptide Metal-Organic Framework by using in-situ powder and single-crystal x-ray diffraction under high-pressures. Crystals of Zn(GlyTyr)2 show a reversible compression by 13 % in volume at 4 GPa that is facilitated by the ability of the peptidic linker to act as a flexible string for a cooperative response of the structure to strain. This structural transformation is controlled by changes to the conformation of the peptide, that enables a bond rearrangement in the coordination sphere of the metal and changes to the strength and directionality of the supramolecular interactions specific to the side chain groups in the dipeptide sequence. Compared to other structural transformations in Zn(II) peptide MOFs, this behaviour is not affected by host/guest interactions and relies exclusively on the conformational flexibility of the peptide and its side chain chemistry.

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Publication details

The article was accepted on 10 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C8DT01765D
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Peptide Metal-Organic Frameworks under pressure: flexible linkers for cooperative compression

    J. Navarro, I. Mullor Ruiz, C. Popescu, D. Santamaria, A. Segura, D. Errandonea, J. González-Platas and C. Martí-Gastaldo, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT01765D

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