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Bispidines for Radiopharmaceuticals


The very rigid tetra-, penta-, hexa-, hepta- and octadentate bispidine ligands are well preorganized for specific coordination geometries. The broad range of coordination numbers, geometries and donor sets allows to design and prepare bispidines for many specific metal ions and applications. Major requirements for radiopharmaceuticals are efficient labeling, inertness under physiological conditions and easy functionalization of the ligands with biological vectors. Reasons, why bispidines are among the most favorable chelators for radiopharmaceutical applications, a comprehensive list of bispidine ligands and a range of examples where bispidines have been used to develop radiopharmaceuticals for future applications in diagnosis and therapy are discussed and presented.

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Publication details

The article was received on 22 Mar 2018, accepted on 16 May 2018 and first published on 17 May 2018

Article type: Perspective
DOI: 10.1039/C8DT01108G
Citation: Dalton Trans., 2018, Accepted Manuscript
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    Bispidines for Radiopharmaceuticals

    P. Comba, M. Kerscher, K. Rück and M. Starke, Dalton Trans., 2018, Accepted Manuscript , DOI: 10.1039/C8DT01108G

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