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Issue 23, 2018
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Electrostatic self-assembled nanoparticles based on spherical polyelectrolyte brushes for magnetic resonance imaging

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Abstract

Magnetic resonance imaging (MRI) is one of the most important medical imaging techniques for clinical diagnosis. Contrast agents (CAs) are commonly necessarily used to enhance the imaging quality of MRI and differentiate diseased tissues from normal ones. Herein, we introduced a macromolecular carrier, spherical polyelectrolyte brushes (SPBs), which consists of a solid polystyrene (PS) core and polyacrylic acid (PAA) chains as a brush layer to host Gd(III) complexes. The cationic Gd(III) complex Gd-DTPA-NO-C4 was synthesized through a 6-step approach and then formed electrostatic self-assemblies with SPBs to afford magnetic assemblies. The regular appearance of the core–shell type structure of the assemblies was confirmed by TEM and SEM. Besides, a remarkable enhancement in relaxivity up to 62 mM−1 s−1 of these assemblies was determined, much higher than that of clinically used small molecule CAs (4–5 mM−1 s−1). It is noteworthy that the assemblies exhibit non-cytotoxicity even at the concentration of Gd(III) up to 150 μM, showing great potential for clinical MRI applications.

Graphical abstract: Electrostatic self-assembled nanoparticles based on spherical polyelectrolyte brushes for magnetic resonance imaging

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Publication details

The article was received on 20 Mar 2018, accepted on 18 Apr 2018 and first published on 19 Apr 2018


Article type: Paper
DOI: 10.1039/C8DT01069B
Citation: Dalton Trans., 2018,47, 7663-7668
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    Electrostatic self-assembled nanoparticles based on spherical polyelectrolyte brushes for magnetic resonance imaging

    W. Qian, Q. Zhu, B. Duan, W. Tang, Y. Yuan and A. Hu, Dalton Trans., 2018, 47, 7663
    DOI: 10.1039/C8DT01069B

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