Enabling strategies for step efficient syntheses

Abstract

The field of natural product total synthesis has reached the point where synthetic efficiency has become more important than merely defining a viable (yet less ideal) route to the target molecule. Synthetic efficiency is best represented by the number of steps it takes to finish the target molecule from readily available starting materials, as by reducing the number of steps, all other factors of synthetic efficiency are influenced positively. By comparing several total syntheses from the recent years, the most successful strategies for step efficient syntheses will be highlighted. Each synthesis will be presented using a color-coded synthetic flowchart, in which each step is categorized by a colored box. Five categories of transformations are defined and rated according to their synthetic value. Each class will be signified by different colors so that the reader can quickly see which parts of the synthesis are productive and those that are not.