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Liposomes and polymersomes: a comparative review towards cell mimicking

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Abstract

Cells are integral to all forms of life due to their compartmentalization by the plasma membrane. However, living organisms are immensely complex. Thus there is a need for simplified and controllable models of life for a deeper understanding of fundamental biological processes and man-made applications. This is where the bottom-up approach of synthetic biology comes from: a stepwise assembly of biomimetic functionalities ultimately into a protocell. A fundamental feature of such an endeavor is the generation and control of model membranes such as liposomes and polymersomes. We compare and contrast liposomes and polymersomes for a better a priori choice and design of vesicles and try to understand the advantages and shortcomings associated with using one or the other in many different aspects (properties, synthesis, self-assembly, applications) and which aspects have been studied and developed with each type and update the current development in the field.

Graphical abstract: Liposomes and polymersomes: a comparative review towards cell mimicking

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Publication details

The article was received on 11 Mar 2018 and first published on 04 Sep 2018


Article type: Review Article
DOI: 10.1039/C8CS00162F
Citation: Chem. Soc. Rev., 2018, Advance Article
  • Open access: Creative Commons BY license
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    Liposomes and polymersomes: a comparative review towards cell mimicking

    E. Rideau, R. Dimova, P. Schwille, F. R. Wurm and K. Landfester, Chem. Soc. Rev., 2018, Advance Article , DOI: 10.1039/C8CS00162F

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