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Issue 12, 2018
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Catalytic enantioselective aldol reactions

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Abstract

Recent developments in catalytic asymmetric aldol reactions have been summarized. Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl compounds in optical pure form, and as such, numerous successful chiral catalysts were designed and applied for asymmetric aldol reactions. This review article is organized under the categories of: (1) catalytic enantioselective aldol reactions of preformed enolates, (2) catalytic enantioselective direct-type aldol reactions using chiral metal catalysts, (3) catalytic enantioselective direct-type aldol reactions using organocatalysts, (4) catalytic enantioselective aldol reactions in aqueous media. Examples of the aldol reactions that employ simple carbonyl compounds will be also the focus of this review.

Graphical abstract: Catalytic enantioselective aldol reactions

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Publication details

The article was received on 03 Dec 2017 and first published on 30 May 2018


Article type: Review Article
DOI: 10.1039/C7CS00824D
Citation: Chem. Soc. Rev., 2018,47, 4388-4480
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    Catalytic enantioselective aldol reactions

    Y. Yamashita, T. Yasukawa, W. Yoo, T. Kitanosono and S. Kobayashi, Chem. Soc. Rev., 2018, 47, 4388
    DOI: 10.1039/C7CS00824D

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