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Issue 11, 2018
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Recent advances in spirocyclization of indole derivatives

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Abstract

Spiroindolines and spiroindoles are an important class of spirocyclic compounds present in a wide range of pharmaceuticals and biologically important natural alkaloids. Various spiroindolines and spiroindoles possess versatile reactivity which enables them to act as precursors for other privileged heterocycles. In view of the importance of this scaffold, many researchers focused their efforts to develop facile and mild synthetic methods for spirocyclization of indoles. However, the synthesis of spiroindolines and spiroindoles is known to be difficult due to rapid 1,2-migration to restore aromaticity. This review aims to briefly discuss the latest developments to access highly functionalized spiroindolines and spiroindoles to stimulate further research in the field to find new and efficient methodologies for accessing new spiroindolines and spiroindoles.

Graphical abstract: Recent advances in spirocyclization of indole derivatives

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Publication details

The article was received on 04 Dec 2017 and first published on 10 Apr 2018


Article type: Tutorial Review
DOI: 10.1039/C7CS00508C
Citation: Chem. Soc. Rev., 2018,47, 3831-3848
  • Open access: Creative Commons BY license
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    Recent advances in spirocyclization of indole derivatives

    J. Bariwal, L. G. Voskressensky and E. V. Van der Eycken, Chem. Soc. Rev., 2018, 47, 3831
    DOI: 10.1039/C7CS00508C

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