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Reduction of graphene oxide quantum dots to enhance the yield of reactive oxygen species for photodynamic therapy

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Abstract

The production of reactive oxygen species (ROS) from graphene oxide quantum dots (GOQDs) and chemically reduced GOQDs (rGOQDs) was studied. This shows that GOQDs and rGOQDs produce ROS including singlet oxygen (1O2), hydrogen peroxide (H2O2) and superoxide anion (O2˙). Interestingly, the rGOQDs exhibit a higher yield of ROS under white light in comparison with GOQDs, indicating the enhanced photodynamic effect through chemical reduction of GOQDs. Studies on the relation between their structures and the yield of ROS demonstrate that the reduction of GOQDs with hydrazine hydrate decreases the band gap and valence band of GOQDs and results in more electron–hole pairs, which leads to an improvement in the yield of ROS from rGOQDs. This research explores the specific species of ROS generated from GOQDs, and provides an efficient avenue to improve the yield of ROS through surface modification of GOQDs.

Graphical abstract: Reduction of graphene oxide quantum dots to enhance the yield of reactive oxygen species for photodynamic therapy

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Publication details

The article was received on 28 Mar 2018, accepted on 25 May 2018 and first published on 31 May 2018


Article type: Paper
DOI: 10.1039/C8CP01990H
Citation: Phys. Chem. Chem. Phys., 2018, Advance Article
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    Reduction of graphene oxide quantum dots to enhance the yield of reactive oxygen species for photodynamic therapy

    Y. Zhang, C. Yang, D. Yang, Z. Shao, Y. Hu, J. Chen, L. Yuwen, L. Weng, Z. Luo and L. Wang, Phys. Chem. Chem. Phys., 2018, Advance Article , DOI: 10.1039/C8CP01990H

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