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Issue 35, 2018
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Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

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Abstract

Carboxylate moieties are less considered in the field of pharmaceutical cocrystal research, although they are contained in some important drug substances and cocrystal formers. Here, we demonstrated that an amine–carboxylate intermolecular interaction (N–H⋯OOC) can be used as a supramolecular synthon for pharmaceutical cocrystal design.

Graphical abstract: Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

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Publication details

The article was received on 05 Jul 2018, accepted on 14 Aug 2018 and first published on 14 Aug 2018


Article type: Communication
DOI: 10.1039/C8CE01106K
Citation: CrystEngComm, 2018,20, 5112-5118
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    Amine–carboxylate supramolecular synthon in pharmaceutical cocrystals

    D. Li, M. Kong, J. Li, Z. Deng and H. Zhang, CrystEngComm, 2018, 20, 5112
    DOI: 10.1039/C8CE01106K

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