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A multi-component mass transfer rate based model for simulation of non-equilibrium growth of crystals

Abstract

A model based on multi-component mass transfer is proposed for modeling the non-equilibrium growth behavior of crystals during solution crystallization. The multi-component composition in crystals in any spatial location can thus be estimated at any time during a crystallization process. It can be applied to estimation of impurity content and assessing stability of crystalline pharmaceuticals. The multi-components are equally described by diffusion, adsorption and integration equations. The facet growth rates are estimated by the amount of materials grown on the surface divided by material densities and the surface areas. This is unlike conventional facet growth kinetic model in which the growth rate is correlated directly to supersaturation. The modeling method is illustrated by case studies of NaNO3 and KDP crystallization. The dynamic evolution of crystal composition and shape distribution is simulated.

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Publication details

The article was received on 21 Apr 2018, accepted on 03 Jul 2018 and first published on 04 Jul 2018


Article type: Paper
DOI: 10.1039/C8CE00639C
Citation: CrystEngComm, 2018, Accepted Manuscript
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    A multi-component mass transfer rate based model for simulation of non-equilibrium growth of crystals

    Y. D. Shu, Y. Li, Y. Zhang, J. J. Liu and X. Z. Wang, CrystEngComm, 2018, Accepted Manuscript , DOI: 10.1039/C8CE00639C

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