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Issue 24, 2018
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Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

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Abstract

The creation of salts is a frequently used approach for the modification of physicochemical properties of an active pharmaceutical ingredient. Despite the frequency of application, there has been little research into the structural–property relationships of the final material and the nature of the counterion present. This work reports on five new salts of sulfathiazole and compares the energetics of the intermolecular interactions with variation in the crystal packing motifs.

Graphical abstract: Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

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Publication details

The article was received on 16 Apr 2018, accepted on 29 May 2018 and first published on 29 May 2018


Article type: Paper
DOI: 10.1039/C8CE00606G
Citation: CrystEngComm, 2018,20, 3428-3434
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    Structural motifs in salts of sulfathiazole: implications for design of salt forms in pharmaceuticals APIs

    C. C. Seaton, R. R. Thomas, E. A. A. Essifaow, E. Nauha, T. Munshi and I. J. Scowen, CrystEngComm, 2018, 20, 3428
    DOI: 10.1039/C8CE00606G

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