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Issue 13, 2018
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A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

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Abstract

A peptide-based cell permeable synthetic transcription factor is reported, which binds to its target site with high affinity and specificity. When linked to a HAT-binding peptide, it causes significant upregulation of gene expression in a mammalian cell. Such molecules may be developed for selectively activating repressed genes in mammalian cells.

Graphical abstract: A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

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Publication details

The article was received on 03 Dec 2017, accepted on 15 Jan 2018 and first published on 15 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09279B
Citation: Chem. Commun., 2018,54, 1611-1614
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    A peptide-based synthetic transcription factor selectively activates transcription in a mammalian cell

    K. Roy, A. Mazumder, P. Ghosh, G. Naiya, B. Ghosh and S. Roy, Chem. Commun., 2018, 54, 1611
    DOI: 10.1039/C7CC09279B

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