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ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Abstract

An ESIPT-based AND logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO- and biological thiols. GSH-ABAH was shown to have good cell permeablility and with the addition of just SIN-1 (ONOO- donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO- and GSH added to RAW264.7 cells.

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Publication details

The article was received on 25 Aug 2018, accepted on 11 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06917D
Citation: Chem. Commun., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
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    ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

    L. Wu, H. Han, L. Liu, J. E. Gardiner, A. C. Sedgwick, C. Huang, S. Bull, X. He and T. D. James, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC06917D

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