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Issue 74, 2018
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Catalytic asymmetric synthesis of diphenylbutazone analogues

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Abstract

The asymmetric Michael addition of diphenylbutazone and its analogues to α,β-unsaturated 2-acyl imidazoles has been developed with a chiral-at-metal Rh(III) complex as a catalyst. The corresponding adducts were obtained in good yields (89–98%) with excellent enantioselectivities (up to >99%). The reaction can be conducted on a gram-scale with a low catalyst loading (0.04 mol%) without impacting its efficiency. Moreover, the adducts can be converted into other useful synthetic building blocks.

Graphical abstract: Catalytic asymmetric synthesis of diphenylbutazone analogues

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Publication details

The article was received on 07 Aug 2018, accepted on 21 Aug 2018 and first published on 22 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC06426A
Citation: Chem. Commun., 2018,54, 10479-10482
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    Catalytic asymmetric synthesis of diphenylbutazone analogues

    S. Li and Q. Kang, Chem. Commun., 2018, 54, 10479
    DOI: 10.1039/C8CC06426A

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