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Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

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Abstract

Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.

Graphical abstract: Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

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Publication details

The article was received on 30 Jul 2018, accepted on 03 Sep 2018 and first published on 06 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06199H
Citation: Chem. Commun., 2018, Advance Article
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    Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

    O. Shemchuk, L. Song, K. Robeyns, D. Braga, F. Grepioni and T. Leyssens, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06199H

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