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Issue 74, 2018
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Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles

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Abstract

We report the preparation of protofibrils from oligomeric Aβ40 aggregates, which have been incubated under spatially constrained conditions. The molecular structure of the resultant protofibrils is highly homogeneous, suggesting that the phenomenon of structural polymorphism commonly observed in Aβ40 fibrils may be largely due to multiple nucleation events.

Graphical abstract: Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles

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Publication details

The article was received on 19 Jul 2018, accepted on 17 Aug 2018 and first published on 29 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05882B
Citation: Chem. Commun., 2018,54, 10459-10462
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    Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles

    Y. Lin, Y. Cheng, C. Ho, Z. Guo, S. Huang, M. Org, A. Oss, A. Samoson and J. C. C. Chan, Chem. Commun., 2018, 54, 10459
    DOI: 10.1039/C8CC05882B

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