Jump to main content
Jump to site search

Issue 74, 2018
Previous Article Next Article

Reduction of a platinum(IV) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation

Author affiliations

Abstract

A PtIV prodrug needs to be reduced to PtII by a biomolecule in order to show efficacy. Among biomolecules, those containing an L-Cys residue have the highest potential to be involved in reduction. Tautomerisation from HSCH2CH(NH3+)CO2 to the unusual zwitterion form SCH2CH(NH3+)CO2H is the prerequisite for L-Cys to become a potent reductant at a low pH.

Graphical abstract: Reduction of a platinum(iv) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Jul 2018, accepted on 20 Aug 2018 and first published on 20 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05682J
Citation: Chem. Commun., 2018,54, 10491-10494
  •   Request permissions

    Reduction of a platinum(IV) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation

    A. Chipman, B. F. Yates, A. J. Canty and A. Ariafard, Chem. Commun., 2018, 54, 10491
    DOI: 10.1039/C8CC05682J

Search articles by author

Spotlight

Advertisements