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An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

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Abstract

Herein, an adenosine triphosphate (ATP)-fueled nucleic acid signal amplification strategy based on toehold-mediated strand displacement (TMSD) and fluorescence resonance energy transfer (FRET) was proposed for highly sensitive detection of microRNA-21. More importantly, the target microRNA-21 could be regenerated with ATP as the fuel rather than a nucleotide segment in conventional approaches, which made the proposed strategy simple and efficient due to the high affinity and strength of the aptamer–target interaction.

Graphical abstract: An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

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Publication details

The article was received on 09 Jul 2018, accepted on 04 Sep 2018 and first published on 05 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC05525D
Citation: Chem. Commun., 2018, Advance Article
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    An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection

    Z. Wen, W. Liang, Y. Zhuo, C. Xiong, Y. Zheng, R. Yuan and Y. Chai, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05525D

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