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A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

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Abstract

A general two-step one-pot synthesis process of ynones was developed by cycloaddition of α-keto acids and 1-iodoalkynes followed by a ring-opening reaction. Its easy conditions and novel mechanism endowed it with two distinctive advantages: iodine-atom bonded to C(sp2) remained intact and α-keto acids became a part of the triple bonds in ynones.

Graphical abstract: A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

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Publication details

The article was received on 05 Jul 2018, accepted on 31 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC05429K
Citation: Chem. Commun., 2018, Advance Article
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    A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

    X. Zeng, C. Liu, W. Yang, X. Wang, X. Wang and Y. Hu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05429K

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