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Biotin-tagged fluorescent sensor to visualize ‘mobile’ Zn2+ in cancer cells

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Abstract

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images ‘mobile’ Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

Graphical abstract: Biotin-tagged fluorescent sensor to visualize ‘mobile’ Zn2+ in cancer cells

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Publication details

The article was received on 05 Jul 2018, accepted on 27 Jul 2018 and first published on 07 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05425H
Citation: Chem. Commun., 2018, Advance Article
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    Biotin-tagged fluorescent sensor to visualize ‘mobile’ Zn2+ in cancer cells

    L. Fang, G. Trigiante, C. J. Kousseff, R. Crespo-Otero, M. P. Philpott and M. Watkinson, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05425H

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